우리나라에서는 매년 약 2,500-4,000명의 뇌종양 환자가 발생하며 인체에 발생하는 전체 종양 중에서 세번째로 많은 비율인 약 10%를 차지한다. 원발성 뇌종양은 두개강내에 뇌조직을 구성하는 세포에서 발생한 것으로 다른 신체의 장기로 전이 되지 않는다. 그러나 원발성 뇌종양의 50%이상이 WHO가 4단계로 분류한 악성도 Ⅲ와 Ⅳ로 악성이며 정상 뇌조직과 경계가 불분명하고 주변 뇌 조직으로 암세포 전이가 빨라 질환의 위중도가 높다.
Purpose: The purpose of this study was to identify the lipid profile ratios as factors affecting disease progress in patients with high-grade primary brain cancers undergoing concurrent chemoradiotherapy (CCRT) and adjuvant chemotherapy. Methods: The levels of lipid profile ratios were evaluated by looking at the total cholesterol (TC) to high-density lipoprotein (HDL)-cholesterol (TC/HDL-c), low-density lipoprotein (LDL)-cholesterol to HDL-cholesterol (LDL-c/HDL-c), and triglycerides to HDL-cholesterol (TG/HDL-c). This descriptive research was conducted 7 months after the initiation of CCRT and adjuvant chemotherapy. Results: A total of 36 patients with newly diagnosed primary malignant brain cancer were included in the study. The levels of lipid profile ratios such as TC/HDL-c, LDL-c/HDL-c, TG/HDL-c were significantly different between the patients with and without disease progress at 7 months after initiation of CCRT and adjuvant chemotherapy. Conclusion: The lipid profile ratios were indicators affecting disease prognosis with tumor-related factors at 7 months after initiation of CCRT and adjuvant chemotherapy. Therefore, lipid profile ratios indicating hyperlipidemia in patients with high-grade brain cancers should be carefully monitored during and after cancer-related therapy.
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