pISSN : 2383-6415   eISSN : 2383-6423

Effect of Environmental Factors on Depressive-like Behavior and Memory Function in Adolescent Rats


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AUTHOR :
Song Min Kyung 
Lee Jae-Min 
Kim Yoon Ju 
Lee Joo Hee 
Kim Youn-Jung 

INFORMATION : page. 276~283 / 2017 Vol.19 No.4


ABSTRACT

Purpose: The aim of this study was to identify the effects of environmental factors on depressive-like behavior and memory function during adolescence. We performed behavior tests in adolescent rats exposed to environmental enrichment, handling, and social deprivation for eight weeks. Methods: Wistar rats were randomly assigned to control, environmental enrichment, handling, and social deprivation groups at the age of four weeks. Results: In the forced swim test, the immobility time in the environmental enrichment group was decreased than that in the control group (p=.038), while the immobility time in the social deprivation group was increased than that in the control group (p=.035), the environmental enrichment group (p<.001), and the handling group (p=.001). In the Morris water maze test, the social deprivation group had an increased latency time than the control group (p=.013) and the environmental enrichment group (p=.001). In the passive avoidance test, the environmental enrichment group had an increased latency time than the control group (p=.005). However, the social deprivation group had reduced latency time than the socially housed groups (control: p=.030; environmental enrichment: p<.001; handling: p<.001). Conclusion: These findings suggest that environmental factors play an important role in emotion and memory function during adolescence.

Keyword :

Adolescent,Social environment,Depression,Cognition


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19 Volumes, 4 Issues, 433 Articles








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