pISSN : 2383-6415   eISSN : 2383-6423

A Comparison between Effects of Anorexia Induced by Consecutive Low-Dose Cisplatin and High-Dose Cisplatin on Hindlimb Muscles of Rats


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INFORMATION : page. 49~56 / 2012 Vol.14 No.1


ABSTRACT

시스플라틴(cis-Diammineplatinum(II) dichloride, CDDP)은 백금화합물로 탁월한 항암효과를 가지고 있어 고형암의 치료에 가장 많이 사용되는 항암제 중 하나이다(Decatris, Sundar, & O’Byrne, 2004). 특히 두경부, 폐, 고환, 난소, 유방 및 폐 등의 고형암 치료에 중요한 역할을 차지하고 있다(Hanigan, & Devarajan, 2003). 그러나 이러한 중요성에 반해 시스플라틴이 가지고 있는 부작용으로 인해 치료효과가 제한적인 것으로 알려져 있다(Decatris et al., 2004). 일반적으로 임상에서 이용되는 항암치료는 고용량 항암제를 투여 후 긴 휴약기간(washout period)을 가지는 방법의 고용량 항암제 투여요법으로 암세포를 직접 죽이거나, 증식을 막는 효과를 갖지만 대상자는 심한 부작용을 경험하는 것으로 보고되고 있다(Bocci, Francia, Man, Lawler, & Kerbel, 2003; Park et al., 2010). 특히 시스플라틴을 고용량으로 투여받은 대상자는 신독성, 이독성, 신경독성, 간독성 등의 부작용을 경험하게 된다(Authier, Gillet, Fialip, Eschalier, & Coudore, 2003; Hanigan & Devarajan, 2003; Glendenning et al., 2010). 또한 위 정체, 위 팽창, 설사, 위장관 운동장애 등의 부작용을 경험할 뿐 아니라 다른 항암제를 투여받은 대상자에 비해 더욱 심한 오심구토를 경험하고 있다(Cabezos, Vera, Martin-Fontelles, Fernandez-Pujol, & Abalo, 2010; Jordan, Kasper, & Schmoll, 2005).

Purpose: The purpose of this study was to compare the effects of anorexia induced by consecutive low-dose and high-dose of cisplatin (CDDP) on the hindlimb muscles of rats. Methods: Male Sprague-Dawley rats were assigned to three groups: Control group (C) received a saline (the same dose and duration as the low CDDP group), the high-dose cisplatin (High CDDP) group received a single 5 mg/kg dose of cisplatin, the consecutive low-dose cisplatin (Low CDDP) group had 1 mg/kg of cisplatin administered for five consecutive days. On the 8th day the soleus and gastrocnemius muscles were dissected. Body weight, food intake, activity, muscle weight, Type I, II fiber cross-sectional area (CSA) of the dissected muscles were measured. Results: Body weight, food intake, muscle weight and Type I, II fiber CSA of the High CDDP and Low CDDP groups were significantly less than the C group. The High CDDP group showed significant decreases, compared to the Low CDDP group, in body weight, food intake, activity score, muscle weight and Type I, II fiber CSA. Conclusion: Hindlimb muscle atrophy occurs due to anorexia induced by both consecutive low-dose and high-dose cisplatin. The muscle atrophy induced by consecutive low-dose cisplatin is less apparent than high-dose cisplatin.

Keyword :

Chemotherapy,Cisplatin,Muscular atrophy,Rat,항암제,시스플라틴,근위축,쥐


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